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WELCOME TO THE LYMPHOMA FOUNDATION |
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BOARD MEMBERS
and SPECIAL
MEMORIAL NOTICES
NEWSLETTERS
EVENTS
FUND RAISING EVENTS
DONATIONS
LINKS TO PATIENT
RESEARCH TRIALS
NCI, NIH, CDC
SPECIAL DATA
ABOUT VITAMIN D
ABOUT THE SHINGLES VACCINE
CLINICIAN SCIENTISTS
LYMPHOMA FOUNDATION GRANT RECIPIENTS
LACHER FELLOWS CONFERENCES
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Members of the Board and Friends
MISSION STATEMENT
OF THE LYMPHOMA FOUNDATION
The Lymphoma Foundation is dedicated to the discovery of innovative
and practical medical therapy by encouraging and supporting creative
clinical and basic research scientists in their quest to find the
cure for all lymphomas and cancer in general
LYMPHOMA
FOUNDATION NEWS
RECENT
EVENTS:
THE FOURTH ANNUAL MORTIMER J. LACHER LECTURE
sponsored by the MSKCC Division of Hematologic Oncology of the
Department of Medicine
was held in the main auditorium of the Zuckerman Research
Building of the Memorial Sloan Kettering Cancer Center... as part of
MEDICAL GRAND ROUNDS on FRIDAY May 17, 2013 starting at 8AM.
The keynote scientific
lecture of this Lacher Day celebration was delivered by
Dr.
Marcel R. M. van den Brink, MD, PhD
Head of the
Division of Hematologic Oncology and an Attending Physician in the
Adult Allogeneic Bone Marrow Transplant Service at Memorial
Sloan-Kettering Cancer Center, the Alan Houghton Professor in
Immunology of the Sloan-Kettering Institute, and Professor of
Medicine and Immunology at Weill Medical College of Cornell
University. Dr. van den Brink's laboratory has made important
discoveries regarding graft-versus-host disease (including the role
of T cell homing, innate lymphoid cells and intestinal stem cell
regeneration), graft-versus-tumor activity (such as post-transplant
tumor vaccines and the role of TRAIL in donor T cell-mediated
graft-versus-tumor effects), and post-transplant immune
reconstitution (adoptive therapy with “off-the-shelf” T cell
precursors, Interleukin-22 and thymic stroma regeneration). This
work is being translated into clinical trials involving
Interleukin-7, Keratinocyte Growth Factor, Leuprolide and T cell
precursors to enhance post-transplant T cell recovery.
In addition... on Friday May 17, 2013 a
meeting was held in the Mortimer Zuckerman Research Building of
MSKCC to further celebrate Lacher Day as the five Lacher Fellows
of the past year (2012-2013) presented their research.
To date…beginning in 1983 with the support of the Lymphoma
Foundation…127 Lacher Fellows have been able to conduct cancer
research under the guidance of senior Sloan Kettering and Memorial
Hospital staff members… for one, two or three years of post
graduate research experience.
The day
after the Grand Rounds meeting…
The 16th ANNUAL BRIAN ROONEY
RUN/WALK
in Central Park, NYC... a fund
raising event for the Lymphoma Foundation in honor and memory of
Brian Rooney was held on SATURDAY AT 10AM May 18, 2013
and after the Race...THE POST RACE PARTY
(included in the Entrance Fee) was held at
RATHBONE'S PUB & GRILL
1702
2nd Ave, New York 10128
(At 88th St)
A key group of volunteers, in addition to
Tricia and Andrew Bresnahan, give their personal talents and time
and money to set up the “Run” in the Park. They are: Erin Leixner,
Rosemary Maxfied, Emily Fleischer, Stu and Eunice Patchen, Frank
Bernabei, Lyle Chernoff, Erin and Chris Moriarty, Frank Cipolla,
Stephanie Fallon, Sara Cooney, Jack Cooney and Aimee Sprogis helps
every year with putting together the flyer. This year Barb Schemera
designed the t-shirt. And each year Annie and Kevin McKenna have
arranged for the venue and the free food at the Party after the Run
for all participants. The Lymphoma Foundation pays for the event
liability insurance plan required by the Parks Department and sends
out announcements of the Run to its own list of potential
participants. The spirit and generosity
of the volunteers over the past 16 years is amazing! And we thank
them for their support of cancer research… especially in this
difficult economic time.
PAST
EVENTS -
THE THIRD ANNUAL MORTIMER J. LACHER LECTURE
sponsored by the MSKCC Division of
Hematologic Oncology of the Department of Medicine
was held in the main auditorium
of the Rockefeller Research Building of the Memorial Sloan
Kettering Cancer Center... as GRAND ROUNDS on FRIDAY May 18, 2012
starting at 8AM. Dr. George Bosl, Chairman of the
Department of Medicine, acted as host of the program and
introduced Dr. Lacher and then Dr. Brian Druker, the guest
Lecturer.
Dr. Brian Druker, a co-discoverer and
developer of Imatinib (Gleevec), a recipient of the Lasker Award and
many other honors for this groundbreaking leukemia
research...reviewed his role in the discovery of Imatinib and its
introduction into clinical trials for the treatment of chronic
granulocytic leukemia.
Later in the afternoon the
MSKCC Lacher Fellows (and their mentors) presented their research of
the past year and Dr. Lacher provided a summation and a review of
the evolution of treatment of the lymphomas, leukemias and other
cancers
The 15th ANNUAL BRIAN ROONEY
RUN/WALK in Central Park, NYC... was held on
Saturday May 19, 2012
and after the race... the post race party was
held at the East End Tavern on First Avenue.
The 14th ANNUAL BRIAN ROONEY RUN/WALK
in Central Park, NYC was held on
Saturday, May 21, 2011.

THE LACHER FELLOWS LYMPHOMA/ HEMATOLOGY/
RADIATION ONCOLOGY RESEARCH CONFERENCE
of the Memorial
Sloan Kettering Cancer Center (MSKCC) was held on Friday
morning, May
20, 2011, in the Zuckerman Research Building
THE SECOND ANNUAL MORTIMER J. LACHER LECTURE sponsored by the MSKCC Division of
Hematologic Oncology of the Department of Medicine
was held on Friday afternoon, May 20, 2011, in the Zuckerman
Research Building...
Kenneth Kaushansky, MD, MACP, Dean School of Medicine, Stony
Brook University was the guest lecturer: Thrombopoietin: From
Cloning to Clinic |
COMPLICATIONS OF SURVIVAL
BREAST CANCER
HEART DISEASE
ABOUT STATIN MEDICATION FOR LYMPHOMA PATIENTS
AND MORE ABOUT HEART AND
ARTERY DISEASE AFTER RADIATION THERAPY
LINKS TO USEFUL
INFORMATION ABOUT THE LYMPHOMAS AND ALLIED CANCERS
FELLOWSHIP RECIPIENTS |
YOUR RESEARCH DOLLARS AT WORK -----
The following research was supported with Lymphoma Foundation
grants:
Janus kinase 2 (JAK2) as a
Therapeutic Target in Graft-versus-Host Disease
Brian Betts, MD Mentor: James Young, MD
Janus kinase 2 (JAK2) is
a principle regulator of
cytokine signaling in inflammation.
We have demonstrated that selective JAK2 inhibition with TG101348
induces allotolerance without impairing viral immunity in vitro.
JAK2 inhibition also extends
survival in a mouse graft-versus-host disease (GvHD) model, without
compromising engraftment. The immunosuppressive effects of JAK2 inhibition are primarily T
cell-dependent, though JAK2 is required for full phenotypic
maturation of monocyte-derived dendritic cell (moDC). JAK2
inhibition preserves baseline levels of allogeneic resting, central
memory, and effector memory T cells, while suppressing CD25, a
marker of alloreactivity, in the central and effector memory
compartments. JAK2 blockade does not impair regulatory T cell (Treg)
expansion, and enhances the Treg:effector ratio in favor of the
Tregs. JAK2 inhibition reduces the production of proinflammatory
cytokines, and impairs the expansion of alloreactive T helper 1
(Th1) and T helper 17 (Th17) cells. TG101348 is a highly selective
JAK2 inhibitor, which ablates JAK2 signaling and preserves JAK3
signaling in T cells.
JAK2 represents a biologically relevant target in preventing and
treating GvHD and allograft rejection, without broader immune
impairment.
Engineering Antigen
Receptors for T-Cell Immunotherapy
Marcela Maus, MD Mentor: Michel Sadelain, MD, PhD
Over the past
decade, the adoptive transfer of T cells has emerged as an effective
therapy in some patients with hematological malignancies or
melanoma. To be more broadly applicable, tumor-reactive T cells
would have to be easily accessible and expandable from any patient.
Recently, several groups have explored retroviral transduction of
autologous T cells with molecularly designed antigen-specific
receptors, either based on native T cell receptors, or chimeric
antigen receptors, or CARs.
The goal of this
project is to develop an approach to target T cells to an
intracellular antigen, focusing on NY-ESO-1 expressing tumors such
as melanoma or myeloma. We have chosen NYESO1 as a target antigen
because of its frequent expression in a wide variety of tumors yet
restricted expression in normal tissues.
The central hypothesis is that an intracellular antigen can
be targeted by retroviral transduction of T cells with either a
chimeric antigen receptor or a T cell receptor that has been
engineered to avoid mispairing. We are also comparing a chimeric
antigen receptor that is based on a TCR-like antibody that is
specific for HLA-A2/NYESO1 peptide to a panel of the engineered TCRs
with the same specificity. In the past year, Dr. Maus has designed
and generated retroviral vectors with a panel of constructs for the
engineered T cell receptors, and has generated preliminary data
showing that an antibody-based chimeric antigen receptor can be
targeted toward an intracellular tumor antigen; however, although
the scFv-based CAR was very specific for HLA-A2 bound to NYESO
peptide when it was generated in soluble form (i.e., an antibody),
we have found that when the same scFv is membrane-bound as part of a
CAR, there is some peptide-independent binding to HLA-A2.
Based on the crystal structure of
the antibody binding to HLA-A2/peptide, a panel of mutants has been
generated in the scFv in an attempt to decrease binding to the
HLA-A2 molecule; testing of these mutants ex vivo and in vivo is
underway.
THE ANNUAL MORTIMER J. LACHER FELLOWS RESEARCH
CONFERENCE
WAS HELD IN THE ZUCKERMAN RESEARCH
BUILDING
OF THE MEMORIAL SLOAN KETTERING CANCER CENTER
Friday May 20, 2011
9:00 – 11:30 AM in Zuckerman 105
Introduction:
Craig
Moskowitz, MD
PRESENTATIONS:
Brian
Betts, MD
Mentor:
James Young, MD
Janus
kinase 2 (JAK2) as a Therapeutic Target in Graft-versus-Host Disease
Marcela
Maus, MD
Mentor:
Michel Sadelain, MD, PhD
Engineering Antigen Receptors for T-Cell Immunotherapy
Jae
Park, MD
Mentor:
Renier Brentjens, MD, PhD
Treatment of B-cell Leukemia with CD19-targeted Genetically Modified
T-cells: The Next Step
Alan
Hanash, MD, PhD
Mentor:
Marcel van den Brink, MD, PhD
Novel
Cytokine Pathways in Graft vs. Host Disease
Christopher Barker, MD
Mentor:
Joachim Yahalom, MD, FACR
Total
Body Irradiation: Past, Present and Future
Concluding Remarks:
Mortimer J. Lacher, MD, FACP
A Historical Review of Clinician Scientists and Their
Accomplishments
at the Memorial Sloan Kettering Cancer Center
THE SECOND ANNUAL
MORTIMER J. LACHER LECTURE
Was held on
Friday May 20, 2011
3:00 – 4:30PM in the Zuckerman Research Building - 105
Guest Lecturer:
Kenneth
Kaushansky, M.D., M.A.C.P.
Sr. Vice President, Health Sciences … Dean, School of Medicine
Stony Brook University
THREE OUTSTANDING CLINICIAN
SCIENTISTS ARE THE NEWEST MEMBERS OF THE BOARD OF THE LYMPHOMA FOUNDATION
Raymond L. Comenzo,
MD is the
Director, Blood Bank and Stem Cell Processing Laboratory, Department
of Medicine, Hematology/Oncology Divisions of the Tufts Medical
Center, Boston, MA
Andrew D. Zelenetz, MD,
PhD, is the
Chief of the Lymphoma Service, Division of Hematology/Oncology,
Memorial Sloan-Kettering Cancer Center, New York, NY
Marcel R. M. van den Brink, MD, PhD,
holds the Alan N.
Houghton Chair and is the Head, Division of Hematologic Oncology at
the Memorial Sloan Kettering Cancer Center, New York, NY
DR. RANDY GASCOYNE WAS THE GUEST LECTURER
AT THE FIRST ANNUAL
MORTIMER J. LACHER LECTURE OF THE MEMORIAL SLOAN KETTERING CANCER
CENTER HELD IN THE ZUCKERMAN RESEARCH BUILDING - MAY 26, 2010
12:30 – 1:30PM in ZRC-105
Randy D. Gascoyne, M.D., Guest Lecturer
Dissecting Hodgkin Lymphoma Biology to Better Understand Treatment
Failure
Clinical Professor of Pathology, University of British
Columbia
Hematopathologist, BC Cancer Agency & the BC Cancer Research
Center
Research Director, Center of Lymphoid Cancers BCCA
FOLLOW
THIS LINK TO
PREVIOUS LACHER FELLOWS RESEARCH CONFERENCES
ON SATURDAY MAY 22nd 2010 ...
A FAMILY FRIENDLY EVENT
THE 13TH
ANNUAL BRIAN ROONEY RUN/WALK
WAS HELD AT 10AM IN CENTRAL
PARK, NEW YORK CITY, THAT RAISED FUNDS FOR LYMPHOMA CANCER RESEARCH
THE POST RACE PARTY AGAIN TOOK PLACE AT THE EAST END TAVERN
(LOCATED BETWEEN 82ND AND 83RD STREET ON FIRST AVENUE) AND
FEATURED DELICIOUS SANDWICH 'WRAPS',
FRUIT SALAD, DESERT AND COOKIES
RESEARCH SUPPORTED BY LYMPHOMA FOUNDATION GRANTS: A
REPORT IN SEPTEMBER 2009
BY M. LIA PALOMBA, M.D.
CHRONIC LYMPHOCYTIC LEUKEMIA (CLL) SIGNALING STUDY: “This
is a collaboration [with myself] and Drs. van den Brink
(Immunology) and Gregoire Altan-Bonnet (Computational Biology)
[Memorial Sloan Kettering Cancer Center] .We
have so far screened 60 samples from patients with CLL with known
prognostic features… and 10 healthy individuals as control. Thawed
peripheral blood mononuclear cells from
patients and healthy volunteers are stimulated with anti-IgM
antibody to cross-link the B cell receptor (BCR) and initiate
signaling events. The cells are then
fixed and permeabilized.
A mixture of surface and intracellular antibodies
recognizing lymphocyte markers and phosphorylated (activated)
signaling
proteins is then used to establish the level of activation in
CD20+/CD5+ B cells in
different patients (CD20+ cells in normal volunteers). We have been
able to show both a higher responsiveness to the B cell Receptor (BCR)
stimulation in CLL B cells compared to
normal B cells and a
high degree of variability among patients.
We
are trying to
establish if there is a correlate between this variability and the
prognostic features
of each patient.
For this purpose we plan to create software that will allow us to
analyze the substantial amount of data generated by flow cytometry
and the
available clinical data and provide an easy graphic representation.”
DIFFICULTY IN THE DEVELOPMENT OF A LYMPHOMA VACCINE: UPDATE
SEPTEMBER 2009: regarding
the CD20 DNA vaccine clinical trial: “This
protocol is a dose-escalation study
of a heteroclitic DNA vaccine, given five times at three week
intervals, using a
fragment of mouse CD20 DNA as the immunogen. Since my last report,
this
study has undergone significant expansion of the eligibility
criteria in order to
improve accrual, which, however, continues to be low. Currently,
eligible patients
must have had at least one prior treatment with chemo- radiation- or
immunotherapy.
All histologies except Burkitt’s lymphoma and lymphoblastic lymphoma
are allowed. Prior autologous stem cell transplant is now allowed.
Because of
concerns of inducing permanent B cell depletion,
the FDA has requested that
each of the first three patients (pre-level 1 cohort) be enrolled in
a staggered
manner and receive a significantly lower DNA dose compared to the
three cohorts of the study in order to be monitored closely for
toxicities. Their circulating B
cells will be serially measured by flow cytometry at established
time points
before, during and after the treatment period.
Our first patient received 4 out of 5 planned vaccinations due to
progression of disease. No depletion of B cells was
observed.
The second patient withdrew from the study before receiving the
first
vaccination. We are in the process of screening 2 more potential
patients for
enrollment this month.”
READ...DEDICATED CLINICIAN
SCIENTISTS TELL YOU…IN THEIR OWN WORDS… ABOUT THEIR PAST ACHIEVMENTS
AND THEIR CURRENT EFFORTS IN FINDING WAYS TO CURE ALL CANCERS
LYMPHOMA FOUNDATION SUPPORTED RESEARCH ACCOMPLISHMENTS

IT TAKES TIME TO EFFECT
CHANGE BUT AS NOTED BELOW...
LYMPHOMA FOUNDATION GRANT SUPPORT FOR PATIENT ORIENTED RESEARCH LED
TO A MAJOR CHANGE IN HODGKIN’S DISEASE TREATMENT
SPEARHEADED BY THE RESEARCH
“Results of a prospective randomized
clinical trial of doxorubicin, bleomycin, vinblastine, and
dacarbazine (ABVD) followed by radiation therapy (RT) versus ABVD
alone for stages I, II, and IIIA nonbulky Hodgkin disease”
published
in the journal
Blood,
1 December 2004, Vol. 104, No. 12, pp. 3483-3489,
a
major change of treatment by many medical oncologists occurred.
Chemotherapy alone is now used for the initial
treatment of most patients with early stage non-bulky Hodgkin
lymphoma… avoiding the initial use of radiation therapy that has a
high incidence of late serious side-effects. And
Dr. David Straus the leader of this Memorial Sloan Kettering
research project wrote to the Lymphoma Foundation: “I am very
grateful for your [the Lymphoma Foundation] support of this study.”
ANOTHER HODGKIN’S STUDY UPDATE:
Dr. Straus reported that as of August 1, 2008 “We have also made
progress in our long-term Hodgkin’s survivor study.
Our protocol, “A Global Assessment of Medical Morbidities and
Quality of Life Among Survivors of Hodgkin Lymphoma” (IRB
#05-041), is nearing completion of enrollment.” And once again, Dr.
Straus noted: “The support of the Lymphoma Foundation has been
invaluable in moving forward these efforts to improve the outcome
for patients with Hodgkin lymphoma, and I am deeply grateful for
your … support.”
LABORATORY AND CLINICAL RESEARCH
FREQUENTLY ADVANCE AT A SNAIL'S PACE
AUGUST 2008
UPDATE OF LYMPHOMA FOUNDATION SUPPORTED RESEARCH REGARDING A VACCINE AGAINST LYMPHOMA
The
CD20 DNA vaccine
developed by the Sloan Kettering research team headed by Dr. Alan
Houghton and assisted by Dr. M. Lia Palomba and many other members
of the Houghton laboratory staff… after over ten years of support by
annual Lymphoma Foundation grants... is finally leaving the
laboratory phase and is entering a clinical patient oriented phase.
This clinical phase is proving to be more difficult than initially
anticipated as the need to protect the patients from any possible
untoward effect of the vaccine has led to extremely stringent and
narrow criteria for entry into the clinical trial and follow-up
care. In this regard… Dr. Palomba informed the Lymphoma Foundation
in August 2008 that “…The
FDA has requested that the first enrolled patient be followed until
completion of all vaccinations and his/her circulating B cells and
quantitative serum immunoglobulins be serially monitored before
enrolling patient
number 2. This will delay accrual of the second patient by about 3-4
months.” Patient
accrual for safety reasons, therefore, will be very slow and the
ultimate test of the value of the vaccine will not be known for many
months to come.
AND also see Lymphoma
Foundation
NEWSLETTERS
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IMPORTANT
DATA
:
ABOUT YOUR VITAMIN D REQUIREMENT
CONCERNING YOUR NEED FOR A HIGHER DAILY INTAKE
OF VITAMIN D
AND CAUTION WITH REGARD TO THE NEW SHINGLES
(HERPES ZOSTER) VACCINE
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MORE
INFORMATION ABOUT VITAMIN D
JULY 2008
FROM: JAMA NEWS in
the
Journal of the American Medical Association
LOW
VITAMIN D LINKED TO INCREASE HEART DEATH
“The
weight of evidence connecting
low vitamin D levels with poor health is getting heavier. One
study published in the June 9
Archives of
Internal Medicine
linked
low levels
of this vitamin in men to an increased
risk of myocardial infarction.
The other, in the June 23 issue of
the same journal, found that
being deficient in this vitamin more than doubled the risk of death
from any cause. "The evidence is just becoming
overwhelming," said Dr. Harald
Dobnig, lead author on the
second paper and professor of internal medicine at the
Medical University of Graz in Austria.
These are the latest studies to
identify low vitamin D as a significant
health risk. Additional analyses
completed on the cohort studied by Dr.
Dobnig and [studies] due to be
published in the
future show that vitamin D status also influences the risk of
cancer and stroke.”
AND a cautionary note:
“Also, while compelling evidence
appears to support the notion that low vitamin D is
unhealthy, less data exist to
signal that increasing consumption
will improve health status. Studies investigating this
premise are forthcoming.
Researchers are pursuing vitamin D supplementation as
possible treatments for a wide
range of health issues
from obesity to diabetes to various forms of cancer.”
OCTOBER 13, 2008
Doubling of Vitamin D for Children Is Urged
as reported
in an ASSOCIATED PRESS release
“CHICAGO (AP) — The country’s leading group of pediatricians is
recommending that children receive double the usually suggested
amount of vitamin D because of evidence that it might help prevent
serious diseases.” “The new advice is based on mounting research
about potential benefits from vitamin D besides keeping bones
strong, including suggestions that it might reduce the risk for
cancer, diabetes and heart disease. But the evidence is not
conclusive, and there is no consensus on how much vitamin would be
needed for disease prevention.”
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PREVIOUS
LYMPHOMA FOUNDATION NEWS -
MULITPLE MYELOMA TREATMENT
ENTERS A NEW PHASE:
IN AUGUST 2007 RAYMOND L. COMENZO, MD REPORTED TO
THE LYMPHOMA FOUNDATION: “Regarding
our current clinical research, we have three protocols open and
accruing that the Lymphoma Foundation is helping to support. The
first is a phase II trial that employs Bortezomib with multiple
other agents for patients with newly diagnosed high-risk multiple
myeloma. The second and third employ Bortezomib for patients with
systemic AL-amyloidosis. One is a phase II trial for newly diagnosed
patients who receive a stem cell transplant and then adjuvant
therapy with Bortezomib and dexamethasone if there is persistent
plasma cell disease. The other is a phase I/II trial for previously
treated patients with relapsed or progressive disease. This trial is
just entering the phase II level. Significant activity was seen
in the phase I portion of the study (25% complete response rate) as
reported at ASCO in June 2007. Clinical research in myeloma is
entering an era of more drugs and increasing complexity. At Memorial
Sloan Kettering Cancer Center our myeloma group is opening trials
for patients with advanced disease employing Bortezomib with 17-AAG
in one case and with Avastin in another. We are seeking approval for
a Bortezomib-based phase II trial as initial therapy in
non-transplant myeloma patients. We also have a phase II
investigator-initiated trial opening soon that uses the new agent
Lenalidomide (Revlimid) and Rituxan for CD20+ myeloma… “We depend
on the help of the Lymphoma Foundation and other supporters to allow
us to stay in the forefront of clinical research in myeloma asking
the hard question -- is early stem cell transplant better?
It is important to note that all the
investigator-initiated trials have translational objectives that are
laboratory-based. The Lymphoma Foundation's support is critical for
these efforts.”
GO TOP
JULY 2007
-
DEVELOPING A CANCER
VACCINE AGAINST LYMPHOMA
—
CONTINUING WORK TOWAD A PATIENT ORIENTED CLINICAL TRIAL OF A CANCER
VACCINE
In the PROGRESS REPORT FOR THE LYMPHOMA FOUNDATION
submitted by
Maria Lia Palomba, MD and Alan N. Houghton, MD they
noted further progress leading toward a cancer vaccine clinical
trial:
PART I: “We
have constructed a set of CD20 vectors with predicted enhanced
immunogenicity based on either the creation of novel MHC
high-affinity epitopes by site directed mutagenesis or by fusing the CD20 DNA (naïve, xenogeneic or
epitopeoptimized) with
fusion partners which our laboratory has shown to improve DNA
vaccines efficacy. We have shown that single amino acid mutations at
anchor residues of MHC
class I epitopes can increase their affinity for the cognate MHC
molecule (1). Using an
algorithm generated in our laboratory, with support of the Lymphoma
Foundation (2), we have identified several potential
heteroclitic epitopes, both in the
extracellular
portion of CD20 and across the entire span of the CD20 protein.
(1) Guevara-Patino, J.A., M.E. Engelhorn, M.J. Turk, C. Liu, F. Duan,
G. Rizzuto,
A.D. Cohen, T. Merghoub, J.D. Wolchok, and A.N. Houghton. 2006.
Optimization of a self antigen
for presentation of multiple epitopes in cancer immunity. J Clin
Invest 116:1382-1390. (2)
Houghton, C.S., M.E. Engelhorn, C. Liu, D. Song, P. Gregor, P.O.
Livingston, F. Orlandi, J.D. Wolchok, J. McCracken, A.N. Houghton,
and J.A. Guevara-Patino.
2007. Immunological validation of the EpitOptimizer program for
streamlined design of heteroclitic epitopes. Vaccine, in
press.”
PART II: JULY 2007 TO THE LYMPHOMA FOUNDATION: BY
Maria Lia Palomba, MD and Alan N. Houghton, MD:
Regarding a clinical
trial of anti-CD20 DNA vaccine in patients with relapsed or
refractory lymphoma:
“We have developed a clinical trial for patients with
relapsed or refractory lymphoma,
and we are in the final stages of attaining approval to begin the
trial, which we anticipate
will be in
the early fall 2007, pending no request to changes to the
protocol:The protocol was approved by the Department of Medicine
Steering Committee, Research Council and passed initial IRB review
at MSKCC (along with several other committees). The protocol was
approved by the Recombinant DNA Advisory Committee of the NIH after
public review and following minor modifications. A pre-IND
teleconference with the FDA raised only minor concerns. Toxicity
studies in rabbits are now completed and show no evidence of toxic
effects.The CD20 vaccine to be used in the proposed study has been
manufactured and vialed, and the
GMP-manufactured product is being stored at MSKCC in the Pharmacy
Department and ready for use following protocol approval by
the FDA. An IND application was recently submitted to the FDA. The
protocol is also simultaneously
undergoing final reviews by the MSKCC Institutional Biosafety
Committee and the Institutional Review Board.
Bringing this vaccine to clinical
trials has been challenging but we are delighted to report
that the clinical trial should begin in the next few months.”
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NOTEWORTHY
INFORMATION: About
the development of second cancers and heart disease after successful
lymphoma treatment...
Lymphoma specialists continue to try to
figure out the best way to adjust the initial methods of therapy for
all lymphoma patients and especially for Hodgkin's
patients that will continue to confer
long life but will avoid the late occurring development of second
cancers (especially breast cancer) and cardiovascular damage induced by the radiation and
chemotherapy.
Women
must
do everything possible to try to detect the development of a second
primary breast cancer at the earliest stage that may still be curable...
by diligent attention to obtaining their mammograms (see
data concerning the value of mammography).
Second cancers
induced primarily by a late effect of radiation is a continuing
dilemma that is not easily solved. On the one hand radiation therapy
can confer a long life free of the primary lymphoma and then, much
later in life, it is the source of the development of a wide variety
of second cancers that are still very difficult to treat.
The death of a
young man from colon cancer 16 years after he was first treated for
Hodgkin's disease highlights this ongoing clinical
problem.
A special memorial note
about David Klein who succumbed to an uncontrollable colon cancer at
the age of 38, sixteen years after he was first treated for
Hodgkin's disease... may be found among the
SPECIAL MEMORIAL NOTICES on the Board Members page. Also note: David's extraordinary memoir
Savoring Life in Sickness and Health
is still available. Go to the
Publications page for a post office address or email
address to obtain a copy.
YOUR ATTENTION
PLEASE...
PRESERVING LONG LIFE BY ADDING A
STATIN TO YOUR 'DIET'
Ask your doctor to check your LDL-Cholesterol.
It is more important than your total cholesterol.
New data indicates that
the 'old' guidelines may have to be revised and your goal should be an LDL-Cholesterol
of 70 (seventy) or lower. For
more information see the
LYMPHOMA FOUNDATION NEWSLETTERS
concerning Editorials about the value of statin medication,
"THE IDEAL CHOLESTEROL: Lower is better" and
the dilemma concerning the best treatment for Follicular Lymphomas
and summaries of work supported in part by Lymphoma
Foundation grants.
ALSO
GO TO: HEART and ARTERY CHANGES
AFTER TREATMENT and
review
Commentary by Clinical and Basic
Research Scientists receiving grant support from the
Lymphoma Foundation to help you appreciate their efforts and
accomplishments regarding vaccine therapy, monoclonal antibody
treatments, the role of genetics in preventing or causing cancer,
advances in the treatment of ovarian cancer, stem cell
transplantation, radiation and chemotherapy to treat Hodgkin's
disease, the non-Hodgkin's lymphomas, leukemia and myeloma and the
unique role of the telomere in aging and cancer causation.
FOLLOW
THIS LINK TO THE
LACHER FELLOWS RESEARCH CONFERENCES
THE 10TH ANNUAL BRIAN
ROONEY RUN/WALK
IN CENTRAL PARK, NEW YORK CITY WAS HELD SATURDAY MORNING MAY 19,
2007 and once again the Run was attended by a wonderful group of
'runners' and 'walkers'. After the Run at Snapper Creek Tavern a
delicious luncheon buffet was enjoyed by the participants
Proceeds from the run
will be supplemented by the Lymphoma Foundation to distribute grants
for the support of basic lymphoma cell research, monoclonal
anti-body research for non-Hodgkin's lymphoma and continuing
clinical trials and improvements in stem cell transplantation for
relapsing lymphoma
The
Ninth Annual Lymphoma Foundation Brian Rooney Run/Walk was held on
Saturday May 20th, 2006 in Central Park, New York City and was
attended by an enthusiastic group of 'runners' and 'walkers'.
After the Run they all enjoyed a delicious luncheon buffet at
Snapper Creek.
This special event is held each spring in memory
of Brian, an avid runner, who died at the age of 32 from non-Hodgkin's
lymphoma... has raised funds each year for the past eight years to support
clinical and basic lymphoma research by Dr. Dennis Cooper, Yale
University, Dr. Gerald Spangrude, University of Utah and Dr. John Leonard,
Cornell University that resulted in adding important data regarding the
basic nature of normal and abnormal lymphocytes, improvements in stem cell
transplantation and the use of newly developed monoclonal antibodies to
treat non-Hodgkin's lymphomas. |
   
The runners got off to a good start while young Colin and Andrew
Bresnahan wondered who would come in first... The first woman runner
seemed to be flying toward the finish line leaving the pack far
behind while some 'walkers' and their dog arrived in a more
leisurely manner.
Read more about the
Rooney Run/Walk in Central Park
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INFORMATION FOR PERSONS WHO
WANT TO LEARN ABOUT HUMAN RESEARCH CLINICAL TRIALS
Many individuals want to know where to
find information concerning patient research trials: Just click on
the ClinicalTrials.gov link and type in the subject
you are looking for. For instance: When you reach the
CLINICAL TRIALS website
type in the words LYMPHOMA
VACCINE and you will be directed to the current lymphoma
vaccine trials. |
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FOLLOW THIS LINK TO
HUMAN RESEARCH TRIALS
http://www.clinicaltrials.gov
This website provides regularly updated information about
federally and privately supported clinical research in human volunteers for all
forms of disease (e.g. Cancer, Heart Disease, etc.). ClinicalTrials.gov gives you information about a trial's purpose, who may
participate, locations, and phone numbers for more details. |
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ATTENTION WOMEN SURVIVORS OF HODGKIN'S DISEASE |
LOWER YOUR CHOLESTEROL LEVELS
WITH STATIN MEDICATIONS:
CHECK OUT DATA
ON THE HEART PAGE
AND THE SEPTEMBER 2005 NEWSLETTER |
American Society of Hematology and American Society of Clinical
Oncology
NATIONAL RESEARCH
MEETING presentations by clinician/scientists supported in part by
grants from the Lymphoma Foundation |
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WHAT YOU SHOULD KNOW ABOUT BREAST CANCER
AND THE NEED FOR EARLY MAMMOGRAPHIC SURVEILLANCE
Early and diligent mammographic screening has been
recommended…
as early as 5 years after the initial radiation therapy even
if that occurs long before the age of 40.
GENETIC RESEARCH of the LYMPHOMAS
and Breast, Ovary and Colon cancer
is supported by Lymphoma Foundation grants (2002-2006)
Special Lymphoma Foundation grants to the Memorial Sloan Kettering Cancer
Center were awarded in 2004-2007 for research directed
toward improving the lives of children with cancer
SUPPORT CANCER RESEARCH
Support the Lymphoma Foundation
MEMORIAL TRIBUTES
David Klein
Joan Rooney
Sr.
Kathleen Toner
Edward Spiegel
The
hand of tragedy reached out and ended a life of caring and generosity with
the sudden death of Edward Spiegel... another dedicated Board Member
of the Lymphoma Foundation ♥♥♥
THE LYMPHOMA FOUNDATION
MISSION AND GOALS |
ATTENTION
ALL PERSONS AND ESPECIALLY THOSE LYMPHOMA PATIENTS WHO RECEIVED RADIATION THERAPY
THERE IS A WAY TO PREVENT CORONARY ARTERY
DISEASE THAT LEADS TO HEART ATTACKS AND PREVENT BLOOD VESSEL
DAMAGE FROM ATHEROSCLEROSIS... THAT MAY LEAD TO A STROKE BY
LOWERING YOUR CHOLESTEROL LEVELS
WITH STATIN MEDICATIONS:
CHECK OUT THE DATA
ON THE HEART PAGE
►►For
detailed information about non-Hodgkin's Lymphoma and Hodgkin's disease
and all forms of cancer:
Connect to links with the National
Cancer Institute and patient research Clinical Treatment Trials
SPECIAL HONORS
2006-2007
On
June 6, 2007 the Department of Radiation Oncology held a special
Grand Rounds at MSKCC honoring the Lymphoma Foundation and Dr.
Mortimer J. Lacher, MD. Brad Hoppe, MD, the
designated Lacher Lymphoma Fellow for 2007-2008 presented and
reviewed the data regarding unique treatments of "Relapsed and
Primary Diffuse Large Cell Lymphoma" ... Michelle Klem, MD,
the Radiation Oncology Lacher Fellow 2005-2006 reviewed the current
Consortium results of the Breast Cancer survey of patients
irradiated for Hodgkin's disease. Dr. Joachim Yahalom introduced the
speakers and Dr. Lacher summarized data with regard to secondary
side-effects of radiation and chemotherapy in lymphoma and other
cancer patients.
John P. Leonard, M.D. was
promoted to Professor of Medicine at Weill Cornell Medical College
and was named the Richard T. Silver Distinguished Professor of
Hematology and Medical Oncology.
Tarun Kewalramani, M.D. was
awarded the Major Family Fund grant and received the Fellows'
Hematology Attending Teaching Award
SPECIAL HONORS
- 2004 - 2005
John P. Leonard, M.D.
received 'First Prize, Department of Medicine Investigator Award,
Weill Medical College of Cornell University
Kenneth Offit, MD was
awarded the American Cancer Society Career Research Recognition Award
Craig Moskowitz, MD
was promoted to Associate Member of the Memorial Sloan Kettering Cancer
Center
Carol Aghajanian, MD
was named Chief of the Gynecologic Medical Oncology Service of the MSKCC
Department of Medicine
On June 7, 2005 the New York Cancer Society
and the Fund for Blood and Cancer Research honored Mortimer J. Lacher,
M.D., President of the Lymphoma Foundation, with the CATHERINE MARGARET PASMANTIER AWARD FOR HIS OUTSTANDING ACCOMPLISHMENTS in the FIELD OF
LYMPHOMA On October 16, 2004
the Center for Lymphoma and Myeloma of the Weil Medical College of
Cornell University and The New York Presbyterian Hospital presented
The
JOHN ULTMANN AWARD to Mortimer J. Lacher, M.D.
FOR HIS OUTSTANDING CONTRIBUTIONS TO PATIENT CARE, RESEARCH AND
EDUCATION IN THE LYMPHOMAS |
DURING
2007-2008
LYMPHOMA
FOUNDATION RESEARCH GRANTS WERE AWARDED FOR:
►High-dose
chemotherapy and stem cell transplantation for large cell lymphoma
and relapsed and refractory Hodgkin’s disease.
►A
patient oriented clinical trial of a DNA vaccine against CD20
antigen expressed by lymphoma cells.
►Further
assessment of novel monoclonal antibodies in B-cell malignancies
(e.g. Epratuzumab, an anti-CD22 monoclonal antibody).
►Evaluation
of combination regimens with rituximab and biologic agents
(including IL-2, anti-CD80, revlimid (lenalidomide) and CpG
immunostimulatory oligonucleotides).
►Studies
of radioimmunotherapy as part of initial therapy for lymphoma (e.g.
fludarabine + I-131 tositumomab).
►New
trials of chemotherapy regimens using bendamustine, a
chemotherapeutic agent that has demonstrated activity in patients
with chemo-resistant and rituximab-resistant disease.
►The
use of new approaches to the treatment of multiple myeloma.
►Seeking
genetic modifiers that are protective against various forms of
cancer (e.g. lymphoma, breast cancer and colon cancer).
►Devising
new effective treatments for patients with low grade lymphoma and
chronic lymphocytic leukemia.
►Defining
the genetic makeup of the Neurofibromas that may lead to an
effective treatment for patients with NF1.
►Initiatives
in assessing lymphoma patients’ survivorship after treatment to
better understand
the needs and problems of our patients who are in
remission after therapy.
DURING
2005-2006
LYMPHOMA
FOUNDATION RESEARCH GRANTS WERE AWARDED FOR:
►CONTINUING DEVELOPMENT
OF VACCINES AGAINST LYMPHOMA and other cancers - Dr. Alan Houghton
and Dr. David Scheinberg - MSKCC
►IMRT
- INTENSITY MODULATED RADIATION THERAPY - Dr. Joachim Yahalom - MSKCC
►SPECIAL
STUDY OF THE RELATIONSHIP OF RADIATION THERAPY TO BREAST CANCER - Dr. Joachim Yahalom - MSKCC
►RESEARCH OF AGING and NF1 --
NEUROFIBROMATOSIS -Dr. Christopher Counter - Duke University - Dr. Kenneth
Offit - and Dr. Suresh Jhanwar - Memorial Sloan Kettering Cancer Center
►CONTINUING DEVELOPMENT
OF TARGETED ALPHA PARTICLE and ATOMIC NANOGENERATORS - Dr. David
Scheinberg - MSKCC
►CHEMOTHERAPY
OF HODGKIN'S AND NON-HODGKIN'S LYMPHOMAS and OVARIAN CANCER - Dr. Tarun
Kewalramani,, Dr. David Straus, Dr. Carol Aghajanian, Dr.Paul Sabbatini -
MSKCC;
►STEM CELLS
and
TRANSPLANTATION - Dr. Craig Moskowitz, Dr. Stephen Nimer - MSKCC;
Dr.Dennis Cooper - Yale University; Dr. Gerald Spangrude - University of
Utah
►MONOCLONAL ANTIBODY THERAPY-- ANTI-LEUKEMIA THERAPY.. PROTEASOME INHIBITORS.. MYELOMA - Dr. Owen
O'Connor, Dr. Raymond Comenzo - MSKCC; Dr. John Leonard - Cornell
University
►GENETICS - Dr. Kenneth Offit
- MSKCC
SPECIAL
JUNE
2009MEETING
THE MEMORIAL SLOAN KETTERING LYMPHOMA/HEMATOLOGY/ AND RADIATION THERAPY FELLOWS SEMINAR
will
be held in June
2009 in the Memorial Sloan Kettering Cancer
Center Rockefeller Research Laboratory Building
NATIONAL RESEARCH
MEETINGS
The annual meeting of the AMERICAN SOCIETY OF HEMATOLOGY
- will be held in December 2009
The annual meeting of the AMERICAN SOCIETY
OF CLINICAL ONCOLOGY - June 2009 - See: web site :www.asco.org |
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The Lymphoma Foundation supports outstanding
▲SCIENTISTS
who have contributed
valuable
academic and practical
▲RESEARCH
as evidenced by their
peer-reviewed ▼PUBLICATIONS.
The
▲
BOARD
of the Lymphoma Foundation has also reached
out to find unique ways to support the research and education of Oncology/Hematology
▲
FELLOWS.
Through the Marie Project Initiative of the Lymphoma Foundation special
efforts are supported that will lead to the prevention and cure of
▲BREAST
CANCER
▲HEART DISEASE -
AND
THE IMPORTANCE of CONTROLLING YOUR CHOLESTEROL
▲EVENTS
and SCIENTIFIC MEETINGS |
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CONTACT THE LYMPHOMA FOUNDATION
CALL THE LYMPHOMA FOUNDATION AT
212-831-5332
EMAIL US:
LYMPHOMA@AOL.COM
with your name and address and your request.
►►►
AND ON THE INTERNET YOU CAN
LEARN MORE ABOUT THE LYMPHOMAS and ALLIED MEDICAL PROBLEMS BY LOGGING ON TO THE
WEBSITE LINKS LISTED ON THE
CONTACT
PAGE |
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You can also write to the Lymphoma Foundation at the
following address:
The Lymphoma Foundation P.O. Box 286236 New York, New York 10128
GO TOP
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▲SCIENTISTS
▲RESEARCH
▲
EVENTS
▲
BOARD
▲
FELLOWS
▲BREAST
CANCER HEART DISEASE
▼PUBLICATIONS
▼CONTACT
US

The Lymphoma Foundation is a nationwide not for
profit foundation dedicated to funding clinical and basic laboratory cancer
research and applying the knowledge developed by the clinician scientists to the general welfare
and education of all cancer patients.
© Copyright THE LYMPHOMA
FOUNDATION All rights reserved |
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